Cohen JN, Kolluri G, Clancy S, Gouirand V, Macon CE, Kalekar LA, Rosenblum MD. Regulatory T cells in skin utilize the Cxcr4-Cxcl12 axis to promote hair follicle regeneration. Cell Rep. 2025 Nov 25;44(11):116467. doi: 10.1016/j.celrep.2025.116467. Epub 2025 Oct 22. PMID: 41129319; PMCID: PMC12871648.
Macon CE, Yang A, Patel D, North JP, Rosenblum MD, Cohen JN. CD4+ T Cells Occupy Perivascular and Perifollicular Niches in Healthy Human Skin. Exp Dermatol. 2024 Dec;33(12):e70023. doi: 10.1111/exd.70023. PMID: 39673225.
Pukhalskaya T, Finkelstein M, Miyake-Caballero DA, Tetzlaff MT, North JP, Cohen JN. Cytokine Profiling of Erythroderma Biopsies Reveals Types 2 and 17 Immune Activation Status. J Cutan Pathol. 2025 Mar;52(3):235-243. doi: 10.1111/cup.14775. Epub 2024 Dec 12. PMID: 39665210.
Sommer C, Cohen JN, Dehmel S, Neuhaus V, Schaudien D, Braun A, Sewald K, Rosenblum MD. Interleukin-2-induced skin inflammation. Eur J Immunol. 2024 Apr;54(4):e2350580. doi: 10.1002/eji.202350580. Epub 2024 Mar 2. PMID: 38430129; PMCID: PMC11015984.
Cohen JN, Gouirand V, Macon CE, Lowe MM, Boothby IC, Moreau JM, Gratz IK, Stoecklinger A, Weaver CT, Sharpe AH, Ricardo-Gonzalez RR, Rosenblum MD. Regulatory T cells in skin mediate immune privilege of the hair follicle stem cell niche. Sci Immunol. 2024 Jan 5;9(91):eadh0152. doi: 10.1126/sciimmunol.adh0152. Epub 2024 Jan 5. PMID: 38181095; PMCID: PMC11003870.
Lowe MM, Cohen JN, Moss MI, Clancy S, Adler JP, Yates AE, Naik HB, Yadav R, Pauli M, Taylor I, McKay A, Harris H, Kim E, Hansen SL, Rosenblum MD, Moreau JM. Tertiary lymphoid structures sustain cutaneous B cell activity in hidradenitis suppurativa. JCI Insight. 2024 Feb 8;9(3):e169870. doi: 10.1172/jci.insight.169870. PMID: 38113104; PMCID: PMC10967391.
Boothby IC, Kinet MJ, Boda DP, Kwan EY, Clancy S, Cohen JN, Habrylo I, Lowe MM, Pauli M, Yates AE, Chan JD, Harris HW, Neuhaus IM, McCalmont TH, Molofsky AB, Rosenblum MD. Early-life inflammation primes a T helper 2 cell-fibroblast niche in skin. Nature. 2021 Nov;599(7886):667-672. doi: 10.1038/s41586-021-04044-7. Epub 2021 Oct 27. PMID: 34707292; PMCID: PMC8906225.
Moreau JM, Dhariwala MO, Gouirand V, Boda DP, Boothby IC, Lowe MM, Cohen JN, Macon CE, Leech JM, Kalekar LA, Scharschmidt TC, Rosenblum MD. Regulatory T cells promote innate inflammation after skin barrier breach via TGF-β activation. Sci Immunol. 2021 Aug 27;6(62):eabg2329. doi: 10.1126/sciimmunol.abg2329. PMID: 34452925; PMCID: PMC8958044.
Dhariwala MO, Karthikeyan D, Vasquez KS, Farhat S, Weckel A, Taravati K, Leitner EG, Clancy S, Pauli M, Piper ML, Cohen JN, Ashouri JF, Lowe MM, Rosenblum MD, Scharschmidt TC. Developing Human Skin Contains Lymphocytes Demonstrating a Memory Signature. Cell Rep Med. 2020 Nov 3;1(8):100132. doi: 10.1016/j.xcrm.2020.100132. PMID: 33294857; PMCID: PMC7691438.
Boothby IC, Cohen JN, Rosenblum MD. Regulatory T cells in skin injury: At the crossroads of tolerance and tissue repair. Sci Immunol. 2020 May 1;5(47):eaaz9631. doi: 10.1126/sciimmunol.aaz9631. PMID: 32358172; PMCID: PMC7274208.
Cohen JN, Bowman S, Laszik ZG, North JP. Clinicopathologic overlap of psoriasis, eczema, and psoriasiform dermatoses: A retrospective study of T helper type 2 and 17 subsets, interleukin 36, and β-defensin 2 in spongiotic psoriasiform dermatitis, sebopsoriasis, and tumor necrosis factor α inhibitor-associated dermatitis. J Am Acad Dermatol. 2020 Feb;82(2):430-439. doi: 10.1016/j.jaad.2019.08.023. Epub 2019 Dec 16. PMID: 31859047.
Kalekar LA, Cohen JN, Prevel N, Sandoval PM, Mathur AN, Moreau JM, Lowe MM, Nosbaum A, Wolters PJ, Haemel A, Boin F, Rosenblum MD. Regulatory T cells in skin are uniquely poised to suppress profibrotic immune responses. Sci Immunol. 2019 Sep 6;4(39):eaaw2910. doi: 10.1126/sciimmunol.aaw2910. PMID: 31492709; PMCID: PMC6848056.
Mathur AN, Zirak B, Boothby IC, Tan M, Cohen JN, Mauro TM, Mehta P, Lowe MM, Abbas AK, Ali N, Rosenblum MD. Treg-Cell Control of a CXCL5-IL-17 Inflammatory Axis Promotes Hair-Follicle-Stem-Cell Differentiation During Skin-Barrier Repair. Immunity. 2019 Mar 19;50(3):655-667.e4. doi: 10.1016/j.immuni.2019.02.013. PMID: 30893588; PMCID: PMC6507428.
Yu WY, Berger TG, North JP, Laszik Z, Cohen JN. Expression of programmed cell death ligand 1 and programmed cell death 1 in cutaneous warts. J Am Acad Dermatol. 2019 Nov;81(5):1127-1133. doi: 10.1016/j.jaad.2019.02.063. Epub 2019 Mar 11. PMID: 30872155.
Rouhani SJ, Eccles JD, Riccardi P, Peske JD, Tewalt EF, Cohen JN, Liblau R, Mäkinen T, Engelhard VH. Roles of lymphatic endothelial cells expressing peripheral tissue antigens in CD4 T-cell tolerance induction. Nat Commun. 2015 Apr 10;6:6771. doi: 10.1038/ncomms7771. PMID: 25857745; PMCID: PMC4403767.
Cohen JN, Tewalt EF, Rouhani SJ, Buonomo EL, Bruce AN, Xu X, Bekiranov S, Fu YX, Engelhard VH. Tolerogenic properties of lymphatic endothelial cells are controlled by the lymph node microenvironment. PLoS One. 2014 Feb 4;9(2):e87740. doi: 10.1371/journal.pone.0087740. PMID: 24503860; PMCID: PMC3913631.
Tewalt EF, Cohen JN, Rouhani SJ, Engelhard VH. Lymphatic endothelial cells - key players in regulation of tolerance and immunity. Front Immunol. 2012 Sep 28;3:305. doi: 10.3389/fimmu.2012.00305. PMID: 23060883; PMCID: PMC3460259.
Tewalt EF, Cohen JN, Rouhani SJ, Guidi CJ, Qiao H, Fahl SP, Conaway MR, Bender TP, Tung KS, Vella AT, Adler AJ, Chen L, Engelhard VH. Lymphatic endothelial cells induce tolerance via PD-L1 and lack of costimulation leading to high-level PD-1 expression on CD8 T cells. Blood. 2012 Dec 6;120(24):4772-82. doi: 10.1182/blood-2012-04-427013. Epub 2012 Sep 19. PMID: 22993390; PMCID: PMC3520619.
Cohen JN, Guidi CJ, Tewalt EF, Qiao H, Rouhani SJ, Ruddell A, Farr AG, Tung KS, Engelhard VH. Lymph node-resident lymphatic endothelial cells mediate peripheral tolerance via Aire-independent direct antigen presentation. J Exp Med. 2010 Apr 12;207(4):681-8. doi: 10.1084/jem.20092465. Epub 2010 Mar 22. PMID: 20308365; PMCID: PMC2856027.
Mason NJ, Coughlin CM, Overley B, Cohen JN, Mitchell EL, Colligon TA, Clifford CA, Zurbriggen A, Sorenmo KU, Vonderheide RH. RNA-loaded CD40-activated B cells stimulate antigen-specific T-cell responses in dogs with spontaneous lymphoma. Gene Ther. 2008 Jul;15(13):955-65. doi: 10.1038/gt.2008.22. Epub 2008 Mar 13. PMID: 18337841.
Coughlin CM, Fleming MD, Carroll RG, Pawel BR, Hogarty MD, Shan X, Vance BA, Cohen JN, Jairaj S, Lord EM, Wexler MH, Danet-Desnoyers GA, Pinkus JL, Pinkus GS, Maris JM, Grupp SA, Vonderheide RH. Immunosurveillance and survivin-specific T-cell immunity in children with high-risk neuroblastoma. J Clin Oncol. 2006 Dec 20;24(36):5725-34. doi: 10.1200/JCO.2005.05.3314. PMID: 17179106.