I'm a physician-scientist who investigates the delicate balance between immune tolerance and autoimmunity in the context of skin inflammation and alopecia. My lab gleans mechanistic insights in the complex interplay between the adaptive and innate immune system, and epithelial stem cells and stroma in skin. We leverage a novel technique to manipulate immune cells in a skin-specific manner with innovative experimental models of autoimmune alopecia to uncover mechanisms of epithelial stem cell loss and immune dysfunction. To translate our findings, we utilize patient-derived, archival specimens for single nuclear RNA sequencing and spatial transcriptomics to gain a better understanding of the pathogenesis of skin autoimmunity and alopecia.
As a dermatopathologist, my main clinical interest is to immunophenotype patient biopsy specimens to improve diagnostic accuracy and use biomarkers that that can potentially guide treatment decisions.
Jarish N. Cohen, MD, PhD
Principal Investigator
Assistant Professor, Departments of Dermatology & Pathology
UCSF Dermatopathology and Oral Pathology Service
Email: [email protected]
Current Lab members:
Gayatri Kolluri, M.S Assistant Specialist Department of Dermatology Email: [email protected] |
Shota Hori, Ph.D Visiting Scholar Department of Dermatology Email: [email protected] |
Lab Alumni:
Hiroki Kondo Medical Student Tohoku University Email: [email protected] |