Welcome to the Cohen Lab: Skin and Hair Immunology

Xenium

We are an interdisciplinary lab focused on studying fundamental skin immunology, with a particular interest in trichoimmunology. By combining advanced imaging, functional assays, in vivo models, and multiomic translational studies, we investigate how the adaptive immune system modulates hair follicle stem cells and fibroblasts — and how those signals influence immune tolerance, tissue repair, and alopecia.

What we study?

• Treg and effector T cell cutaneous biology: origin, recruitment, and mechanisms of immune regulation and repair.
• Hair follicle stem cell — immune cell interactions: how stem cells influence immune tone and how immune cells impact stem cell function.
• Autoimmunity and tolerance breakdown: cellular and molecular drivers of autoimmune skin disorders and potential points for therapeutic intervention.
• Translational impact: identifying pathways that could be therapeutically modulated to restore skin immune balance.

Why it matters?

Dysregulated Treg–stem cell interactions can lead to chronic inflammation, impaired healing, and autoimmune disease. Understanding these interactions at cellular and molecular resolution opens new paths for treatments of alopecia and dermatitis that could restore healthy immune tone without broadly suppressing immunity.